AI as a Clinical Assistant: Enhancing MSK Ultrasound Interpretation and Reporting

If you haven’t yet tried using an AI assistant in your clinical practice, now is the time to start.

We are standing at the threshold of a shift in how we work. The rise of large language models (LLMs)—text-based AI systems like Chat GPT that can interpret, generate, and summarize content—offers clinicians a remarkable opportunity: to work faster, think broader, and document smarter. I want to be clear that these tools are still evolving, but their usefulness in the day-to-day reality of musculoskeletal ultrasound is already tangible, even resulting in substantial changes.

An AI-generated image of Dr Wilcox scanning a patient with an AI avatar in the background

In my own sports medicine practice, AI has become a quiet but powerful assistant. It’s not replacing clinical expertise; it’s extending it. Over time, I’ve found a sweet spot—not in making decisions for me, but in helping me think more clearly. One of the most practical ways I use LLMs is for differential generation. I paste in my ultrasound findings and impression and ask for a possible differential diagnosis list. The results are consistently thought-provoking. Typically, it reflects five or six diagnoses I already had in mind; throws in a couple I disagree with outright; and adds two or three that surprise me, and deserve a closer look. Especially in complex or uncertain cases that prompt a pause and consideration of something new that can be invaluable.

Some mainstream AI platforms even promise image interpretation. My experience? These are not yet ready for prime time. Results can be inconsistent; accuracy is still highly variable. But for text-based assistance—where language, not pixels, is the primary input—LLMs can make the difference.

One area where AI shines is in reducing the friction of tedious or repetitive tasks. Prior authorizations, for example, used to eat up valuable time and mental bandwidth. Now, I can copy a de-identified clinical summary and the insurance denial into an LLM and request a short appeal letter. It generates a polished draft that often needs only light editing. Occasionally, I’ll even ask the AI why it thinks the request was denied—it often gives helpful insight I can use in peer-to-peer calls.

The same applies to documentation templates. I’ve built standard templates for common joints, but what about when a patient presents with something less routine, such as a region I haven’t scanned often enough to have a template, like the sternoclavicular joint? I give the model an existing template and ask it to adapt it to the new joint. The results? Fast, accurate, and easy to refine. Here’s a quick look at how I use AI in daily practice:

  • Differential support: Expands my diagnostic horizons, especially in unusual or complex cases.
  • Template generation: Converts existing structures into less common regions or patient types with minimal effort.
  • Prior auths & letters: Speeds up appeal writing; reduces emotional exhaustion from repetitive documentation.
  • Note polishing: Transforms shorthand findings into clean, communicative notes for specialists or patients.

But let’s be clear: none of this replaces the responsibility we carry as clinicians. AI is a powerful tool, but it must be used wisely. A recent study from MIT (Your Brain on ChatGPT) found that users writing essays with AI support showed lower brainwave activity, suggesting a reduction in active cognitive processing. The lesson here is sharp: when we outsource too much thinking, our ability to reason, synthesize, and create diminishes.

We cannot allow that to happen in medicine. What we document, what we diagnose—these remain our responsibility. AI can offer suggestions, but only we can make decisions. Every recommendation must be filtered through our personal, sound clinical judgment.

So yes—use AI to sharpen your workflow, expand your thinking, and save time. But use it with intention. Let it challenge your thinking, not do your thinking. Let it shape your creativity, not replace it. When used well, AI doesn’t flatten our clinical voice; it amplifies it. It helps us become more precise, more efficient, and, most importantly, more present with the people we serve.

References: Kosmyna N, Hauptmann E, Yuan YT, et al. Your brain on ChatGPT: accumulation of cognitive debt when using an AI assistant for essay writing task. Preprint. Submitted June 10, 2025. Accessed 7/8/2025. Available from: https://arxiv.org/abs/2506.08872

James Wilcox, MD, RMSK, is a family medicine and sports medicine physician in the United Arab Emirates, where he is the Director of the ProMotion Sports Medicine Clinic at Specialized Rehabilitation Hospital in Abu Dhabi, and Assistant Professor of Family Medicine at UAE University..

This posting has been edited for length and clarity. The opinions expressed in this posting are the author’s own and do not necessarily reflect the view of their employer or the American Institute of Ultrasound in Medicine.

The Dawn of Large Language Models (LLMs) in Ultrasound

With the advent of large language models (LLMs), such as the well-known ChatGPT, there has been a surge of interest in how to leverage these technologies in healthcare. These queries are far from baseless, as LLMs have already demonstrated significant value in various non-clinical fields. It is entirely reasonable to explore their potential in medical imaging. The biomedical industry has begun to innovate and propose solutions based on the perceived needs of physicians and the medical imaging workforce, often from an engineering standpoint. However, LLMs offer a unique opportunity to develop solutions through a collaborative approach that includes both physicians and industry professionals.

In other words, only by integrating insights from clinicians can we ensure that the benefits of LLMs are realized in ways that genuinely enhance clinical practice. This collaborative approach is particularly relevant in the field of ultrasound imaging, where the unique real-time nature of the modality, combined with operator-dependent variability, presents both opportunities and challenges. This blog post explores the exciting possibilities of LLMs in ultrasound imaging through two specific approaches: scan-time AI assistance and review-time AI assistance.

The Dream: Scan-Time AI by Real-Time Integration of LLMs

Imagine having a smart assistant right by your side during an ultrasound exam, processing data in real time and offering insights instantaneously. This “scan-time AI” is not a distant dream but an emerging reality. By integrating LLMs into ultrasound machines, clinicians can receive immediate feedback on the screen. This AI-powered assistance can highlight areas of interest, suggest potential diagnoses, and recommend additional views or techniques to optimize image quality, making the diagnostic process more accurate and efficient.

However, the journey to seamless real-time AI integration comes with its own set of challenges. The primary hurdle is ensuring that the AI operates with split-second precision, as any lag could disrupt the examination flow. Additionally, the integration must be intuitive, ensuring that AI suggestions complement the clinician’s expertise without causing distraction. The ultimate goal is to create a harmonious partnership where AI augments the clinician’s skills and enhances patient care.

As their name implies, LLMs are designed to communicate with language at the center. Early examples include chat-like communication with the user, which, at first glance, may not seem viable for medical imaging workflows. However, LLM literature is advancing very rapidly, and with the invention of multi-modal LLMs, communication with ultrasound systems will no longer be limited to text but also extend to other modalities such as voice and images. Voice commands can streamline the process, allowing clinicians to focus on the patient and the probe without needing to manipulate controls manually. For instance, a clinician could say, “Compare the thickness of the renal cortex with the medulla” and the ultrasound machine would reason through the command, detect the said anatomical structures, perform the measurement, and display the results, thus improving efficiency and ergonomics. However, voice interaction in a clinical environment brings its own set of complexities. The bustling background noise, the need for precise and unambiguous commands, and the potential for AI misinterpretation are significant factors to consider. Furthermore, voice interaction must be evaluated for its impact on privacy within the clinical setting. When these issues with voice communication in clinical settings are addressed, using LLMs through voice commands for ultrasound examinations will become much smoother and more efficient.

We’re There: Review-Time AI for Post-Examination Analysis

While real-time AI offers immediate benefits during the scan, “review-time AI” focuses on the critical post-scan phase. LLMs can meticulously review ultrasound images and generate detailed reports, highlighting key findings and suggesting differential diagnoses. This application can significantly alleviate the documentation burden on clinicians, allowing them to dedicate more time to patient care.

The necessity for LLMs in review-time AI stems from the sheer volume and complexity of data clinicians must analyze. By automating the initial review and providing structured reports, LLMs enhance the consistency and quality of ultrasound interpretations. This approach also facilitates collaborative care, as AI-generated reports can be easily shared and reviewed by other specialists, ensuring a comprehensive evaluation of the patient’s condition.

A Call to Action for Physicians

Physicians play a pivotal role in shaping the future of AI technologies. While engineers and data scientists provide the technical backbone, clinicians’ insights and feedback are crucial in developing AI systems that truly address healthcare needs. Physicians are encouraged to experiment with these new-age AI tools in their daily routines, providing critical feedback that will steer the evolution of AI in a direction that genuinely enhances clinical practice.

Integrating LLMs into ultrasound imaging is not merely a technological advancement but a paradigm shift that requires active collaboration between clinicians and technologists. By exploring the exciting possibilities of scan-time and review-time AI and addressing the challenges of voice interaction, we can pave the way for a more efficient and accurate diagnostic process. Physicians, your involvement and insights are crucial. Together, we can shape a future where AI not only complements but also elevates the art and science of ultrasound imaging. Let’s embrace this transformative journey and lead the way to a new era of medical innovation.

Utku Kaya is a Co-founder and Chief Executive Officer of SmartAlpha.