Ultrasound plays an increasingly important role in the detection and management of endometriosis, a chronic condition in which tissue similar to the uterine lining grows outside the uterus. Although ultrasound cannot identify every form of the disease, it is a valuable, noninvasive tool that helps clinicians recognize certain patterns of endometriosis and guide treatment decisions.
Endometriosis can affect the ovaries, pelvic ligaments, bowel, bladder, and other structures. Symptoms often include pelvic pain, painful periods, pain during intercourse, and infertility. Because these symptoms overlap with many other conditions, imaging is frequently used as part of the diagnostic workup. Ultrasound is usually the first-line imaging test because it is widely available, has a relatively low cost, and does not expose patients to radiation.
One of the most reliable uses of ultrasound in endometriosis is identifying ovarian endometriomas. These are cysts that form when endometrial-like tissue grows within the ovary. They are sometimes referred to as “chocolate cysts” because of their thick, dark fluid content. On ultrasound, endometriomas typically appear as cystic structures with uniform low-level internal echoes and thick walls. This characteristic appearance allows experienced practitioners to recognize them with a high degree of confidence. Detecting an endometrioma strongly suggests the presence of endometriosis elsewhere in the pelvis as well.
Ultrasound can also be used to detect deep infiltrating endometriosis (DIE), which refers to disease that extends into tissues beneath the surface of the pelvic lining. These areas may include the uterosacral ligaments, the space between the uterus and rectum (the pouch of Douglas), and even the bowel or bladder wall. Advanced transvaginal ultrasound techniques can identify nodules, thickened ligaments, and abnormal tissue planes. Sonographers and physicians also assess how pelvic organs move in relation to one another. Limited movement, known as a negative “sliding sign,” may suggest adhesions caused by endometriosis.
In addition to detection, ultrasound is valuable for mapping disease before surgery. Specialized endometriosis-focused ultrasound exams can help determine how far the disease extends and which organs are involved. This information allows surgeons to better plan procedures, anticipate technical challenges, and determine whether additional specialists, such as colorectal surgeons or urologists, may be needed during surgery. Preoperative mapping can improve surgical outcomes and reduce unexpected findings in the operating room.
Despite its strengths, ultrasound has important limitations. It is not effective at detecting superficial endometriosis—small implants scattered across the pelvic lining. These lesions are often too tiny and too flat to be seen on imaging. For this reason, a normal ultrasound does not rule out endometriosis. Laparoscopy with biopsy remains the gold standard for a definitive diagnosis, especially in patients with persistent symptoms and negative imaging studies.
Ultrasound also plays a role in treatment and ongoing management. It can be used to monitor the size of endometriomas over time and evaluate how pelvic anatomy changes with hormonal therapy. In select cases, ultrasound may guide procedures such as drainage of endometriomas or targeted injections for pain management. For patients seeking pregnancy, ultrasound is especially useful for assessing ovarian reserve, tracking follicle development, and identifying anatomic changes that could interfere with conception or fertility treatments.
Overall, ultrasound is best viewed as a powerful tool within a broader diagnostic strategy. It excels at identifying ovarian endometriomas and, when performed by skilled practitioners, can detect many cases of deep infiltrating disease. However, it cannot detect all forms of endometriosis, particularly early or superficial lesions. When combined with clinical evaluation and, when necessary, surgical diagnosis, ultrasound helps clinicians better understand disease extent, tailor treatment plans, and support patients through both symptom management and fertility planning.
In the evolving landscape of endometriosis care, ultrasound continues to grow in importance as a critical piece of the diagnostic and therapeutic puzzle.
Cynthia Owens, BA, is the Publications Coordinator for the American Institute of Ultrasound in Medicine (AIUM).







