The Growing Role of Ultrasound in Addressing Complications in Aesthetic Medicine

A patient we’ll call Janet contacted our clinic in a state of distress. What began as a seemingly benign bruise a day after her chin and jawline filler injections spread to her cheek and forehead. Subsequently, her eyelids became bruised and edematous, and purple marks appeared on her temple, tracing the path of her arteries. When she sought help from the clinic that administered the injections, the doctor was unavailable. It took days before she was finally diagnosed with vascular occlusion and began treatment, which included hyperbaric oxygen therapy, aspirin, hyaluronidase injections, and even Viagra to improve blood flow. Yet, the sinister purple marks continued to spread, and the areas remained exquisitely painful. With a growing sense of alarm, she reached out to our office.

In aesthetic medicine, few situations are true emergencies. Even with vascular occlusion, like in Janet’s case, there’s typically a treatment window of 2–3 days. However, by the time Janet reached us, that critical period had elapsed, and we found ourselves in a race against time to prevent ischemic tissue damage. Fortunately, our clinic is well equipped for such emergencies, armed with a high-resolution ultrasound device and years of experience.

Filler-related vascular occlusion, with the pain of ischemia, and subsequent treatments, along with the looming threat of facial necrosis and the anxiety over uncertain outcomes, can be a daunting experience for both practitioners and patients. In these situations, ultrasound becomes invaluable. Its ability to provide real-time visualization of affected vessels and the occlusive filler enables precise, ultrasound-guided hyaluronidase injections that dissolve the filler, improve arterial spasm, and restore blood flow. Once the occlusion is treated, Color Doppler can demonstrate immediate improvement in blood flow, correlating with clinical recovery and providing reassurance to both patients and medical practitioners.

Janet’s ultrasound exam revealed several areas of blockage along the facial arteries, with adjacent filler deposits. We found areas of decreased blood flow along the jaw, in her cheek, in the temple, and at the mandibular angle, with large deposits of anechoic hyaluronic acid filler adjacent to them. We also discovered and treated severely decreased flow in the facial vein, which likely explained the unusual periorbital edema and ecchymosis. You can see one area of compromised blood flow in Figure 1.

Figure 1

We treated these areas with ultrasound-guided hyaluronidase injections, as depicted in Figure 2.

Figure 2

By the following day, Janet’s condition had shown marked improvement, and the pain had subsided. Improved blood flow in both the facial artery and facial vein can be seen in Figure 3.

Figure 3

Over the last several years, we have witnessed an exponential increase in the number of aesthetic treatments. However, as we keep pushing the envelope to improve our patients’ results and the longevity of our treatments, we face a growing number of complications, including overfilled faces, filler malposition and migration, lumps, chronic edema, and vascular complications such as vascular occlusion, and even stroke and blindness. Vascular occlusion, one of the most dreaded filler complications, has been the main impetus behind the introduction of ultrasound into aesthetic medicine.

This process could not have come at a better time. The use of ultrasound offers a blend of opportunities and challenges that are reshaping our profession. From mastering facial anatomy and adopting safer injection techniques to managing complications more effectively, aesthetic practitioners can harness the power of ultrasound to advance their practice and patient care, refine techniques, enhance safety, and improve patient outcomes.

References:

  1. Desyatnikova S, Schelke L. Treatment of filler-related vascular occlusion using handheld portable ultrasound device. J Cosmet Dermatol 2022; 21:3166–3168. doi: 10.1111/jocd.15125.
  2. Desyatnikova S, Barrera P. High-resolution ultrasound for diagnosis and treatment of filler-related septal necrosis. Plast Reconstr Surg Glob Open 2024; 12:e5630. doi: 10.1097/GOX.0000000000005630.
  3. Choi SY, Shin SH, Seok J, Yoo KH, Kim BJ. Management strategies for vascular complications in hyaluronic acid filler injections: A case series analysis. J Cosmet Dermatol 2023; 22:3261–3267. doi: 10.1111/jocd.15990.
  4. Schelke LW, Velthuis P, Kadouch J, Swift A. Early ultrasound for diagnosis and treatment of vascular adverse events with hyaluronic acid fillers. J Am Acad Dermatol 2023; 88:79–85. doi: 10.1016/j.jaad.2019.07.032.

Stella Desyatnikova, MD, is a double board-certified facial plastic surgeon, with over 20 years’ experience. She is the founder of The Stella Center for Facial Plastic Surgery and the Ultrasonos Aesthetic Ultrasound Training Center in Seattle, WA. She is a leading authority in aesthetic ultrasound research and education, committed to expanding education and awareness of ultrasound use to optimize safety of aesthetic procedures. Her research is focused on filler injectable safety and facial ultrasound applications. She is the Secretary-elect of the Dermatology Community of the American Institute of Ultrasound in Medicine (AIUM). She is also an International Expert Board Member of the Complications in Medical Aesthetics Cooperative (CMAC) and a member of the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS).

Interested in learning more? Check out the online Advanced Dermatologic Ultrasound Course on September 7–8, 2024, with renowned faculty including Stella Desyatnikova, MD.

Complications of Cosmetic Fillers

Dermatologic Ultrasound—The first modality of choice in the diagnosis and management of complications due to the use of cosmetic fillers

Each day, the use of exogenous materials for aesthetic purposes (known as fillers) is more common. Recent data from the American Society of Plastic Surgery (ASPS) confirmed that it is the second most common noninvasive medical procedure, followed by the use of botulinum toxin.

It has been described that the ideal filler material must meet certain characteristics: be cosmetically effective, not allergenic or induce immunologic reactions, not carcinogenic, not teratogenic, not migrating, biocompatible, biodegradable, and injectable. When used routinely, the technique and the results should be reproducible. Finally, in addition to what is described, it must be cost effective.

Unfortunately, a substance that meets all of these characteristics does not yet exist and, therefore, it is possible that with the use of cosmetic fillers, multiple complications may appear, from very simple to severe disfigurement, irreversible sequelae, and even blindness or hemiparesis. To make the scenario even more difficult, complications can occur with medically approved substances such as hyaluronic acid or with substances not medically approved for cosmetic use such as silicone in oil.

Fillers can be injected by qualified physicians or nonphysicians and constitute a problem of malpractice. In my country, Colombia, this has become such a complex scenario, the complications derived from all these types of products and procedures have been considered a public health problem, and the situation may not be different in other countries of the world.

In many cases, complications can appear early or late, even many years after the filler application, and patients may not remember or even deny the use of them. Their clinical presentation is diverse and imprecise and can simulate multiple dermatologic pathologies. In this complex scenario, the precise diagnosis of these complications represents a clinical and imaging challenge.

Some diagnostic modalities, such as magnetic resonance imaging (MRI), have been used for the characterization of exogenous materials, mainly due to their excellent spatial anatomic resolution but, it is unable to establish precisely the type of substance injected. Although there are silicone suppression sequences, which in theory would allow differentiation of this substance from other types of fillers, the truth is that other types of fillers can have an appearance similar to silicone in MRI, which manifests as “silicone like”, being indistinguishable from each other or with multiple inflammatory skin conditions.

Computerized axial tomography does not have any indication in the identification of these types of substances and positron emission tomography (PET)-CT is not recommended for the evaluation of injectable material because the increase in metabolic activity is not specific and can be seen in patients with or without complications caused by the injection of the fillers.

High-resolution dermatologic ultrasound with linear transducers from 14- to 22-MHz has proven to be a very precise diagnostic tool to differentiate the type of filler injected and the complications derived from them, avoiding misdiagnosis and the use of unnecessary biopsies. Substances such as hyaluronic acid, calcium hydroxyapatite, silicone, polymethylmethacrylate, and polycaprolactone, among others, have a unique and characteristic ultrasound appearance that allows them to be easily differentiated from the others.

Late or early complications such as the development of dermatopathies, hypersensitivity reactions, migration of the filler material, inflammatory and noninflammatory nodules, can also be characterized with dermatologic ultrasound and the differentiation of these complications from diseases such as morphea, sarcoidosis, or cutaneous lymphoma that they may have an identical clinical presentation can be adequately performed by ultrasound. The study must be carried out by personnel with specific training and follow the suggested guidelines for the use of dermatologic ultrasound.

During my almost 10 years dedicated exclusively to dermatologic ultrasound, I have diagnosed many cases with all these types of complications related to the use of filler material, cases with mild complications or devastating stories of patients with sequelae that will mark your life forever. In all of them, ultrasound has provided valuable information with which my clinical colleagues, Dermatologists and Plastic Surgeons, have assertively managed their patients.

Bibliography

  • Worstman X. Identification and complications of cosmetic filler: sonography first. J Ultrasound Med 2015 Jul; 34(7):1163–1172. DOI: 10.7863/ultra.34.7.1163.
  • .Cavallieri F. Adventages of sonography in fillers and complications. In Image Guided Dermatologic Treatments. Switzerland. Springer 2020. pp93–102.
  • González C. High resolution ultrasound of soft tissues for characterization of fillers and its complications. Rev Colomb Radiol 2019; 30(1): 5064–5068
  • Worstman X, Alfagame F, Roustan G, Arias-Santiago S, Martorell A, Catalano O, Scotto M, Zarchi K, Bouer M, González C, Bard R, Mandava A, Gattini D. Guidelines for performing dermatologic ultrasound examinations by the DERMUS group. J Ultrasound Med 2016; 35: e111–e114.

Claudia Gonzalez, MD, is a radiologist at IDIME in Bogotá, Colombia, and is Secretary of the Dermatologic Ultrasound AIUM Interest Group, High Resolution Dermatological and MSK Ultrasound.

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